Cell Biology

Special Issue

Mitochondria: Implications in Human Health and Diseases

  • Submission Deadline: 28 February 2015
  • Status: Submission Closed
  • Lead Guest Editor: Lokendra Sharma
About This Special Issue
Mitochondria play a central role in energy metabolism. It is now well established that functional mitochondria are important in the regulation of several essential cellular metabolic pathways, apoptosis, signal transduction and cell growth. It is of particular importance in the high energy requiring tissues such as brain, heart and muscle. Mitochondrial defects have been implicated in a wide range of clinical conditions such as cancer, neuro-degeneration, obesity, diabetes, ageing and age associated disorders including Parkinson's, Alzheimer's and loss of muscle mass. Since mitochondrial DNA is maternally inherited, mutations in the mitochondrial DNA have also been linked to rare childhood diseases and metabolic syndromes. In recent years tremendous progress has been made in deciphering novel mechanisms of mitochondria in cellular signaling. Rerouting of metabolites in mitochondrial TCA cycle provides alternative ways to generate building blocks such as nucleotides and amino acids for cellular growth and proliferation. Damaged mitochondria are removed through autophagy or functional mitochondria are maintained through enhancing mitochondrial biogenesis. Mitochondrial fission and fusion mechanisms are providing new insights into mitochondrial quality control. In this special issue we will highlight functional aspects of mitochondria in maintaining cellular homeostasis and also the consequences of mitochondrial defects that contributes in disease progression.
Lead Guest Editor
  • Lokendra Sharma

    Center for Biological Sciences, Central University of Bihar, Patna, India

Guest Editors
  • Rosonald Bell

    Pfizer Inc., Groton, United States

  • jack sparrow

    js, China

  • Ashutosh Shrivastava

    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Boston, United States

  • Khyati Dave

    Department of Biodesign, Stanford University, Palo Alto, United States



  • Soroosh Solhjoo

    Johns Hopkins University, Baltimore, United States

  • Cunye Qu

    Center for Craniofacial Molecular Biology, University of Southern California, Losangeles, United States

  • Şirin Korulu Koç

    Department of Molecular Biology and Genetics, Istanbul Arel University, Istanbul, Turkey

  • Meenakshi Tiwari

    Department of Pathology and Laboratory Medicine, AIIMS-Patna, Patna, India

  • Aditya Sen

    Department of Biochemistry and Molecular Biology, Uniformed Services University, Bethesda, United States

  • Soumyabrata Munshi

    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, United States

  • Rizwanul Haque

    Centre for Biological Sciences (Biotechnology), Central University South Bihar, Patna, India

  • Ashok Kumar

    Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Bhopal, India

  • Umesh Wankhade

    NIH, Bethesda, United States

  • Palas Chanda

    Department of Cardiovascular Sciences, Houston Methodist Research Institute, houston, United States

  • Fnu Gaurav

    Department of Surgery, School of Medicine, KU Medical Center, Kansas, United States

  • Lei Wang

    Johns Hopkins University, School of Medicine, Wilmer Eye Institute, Baltimore, United States

  • Saipraveen Srinivasan

    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, United States

  • Yanqing zhang

    , United States

  • Ahmed M.S. Hegazy

    Department of Anatomy and Embryology, Benha Faculty of Medicine, Benha University, Benha, Egypt

  • Masumeh Saeidi

    Department of Medical Education, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Published Articles
  • Mitochondria: A Key Player in Stem Cell Fate

    Nadra Sadaf , Jawaid Ahsan , Saif Ahmad , Rizwanul Haque

    Issue: Volume 3, Issue 2-1, April 2015
    Pages: 31-37
    Received: 28 February 2015
    Accepted: 1 May 2015
    Published: 9 June 2015
    DOI: 10.11648/j.cb.s.2015030201.15
    Abstract: Mitochondria are highly dynamic organelles that undergo cycles of fusion and fission important for their function, maintenance, and quality control as well as direct or indirect role in different types of stem cells fate decisions. Stem cells have potential for numerous biomedical applications; however the major bottle neck in stem cell field is th... Show More
  • Interaction Between Mitochondria and Caspases: Apoptotic and Non-Apoptotic Roles

    Meenakshi Tiwari , Lokendra Kumar Sharma , Ajit K. Saxena , Madan M. Godbole

    Issue: Volume 3, Issue 2-1, April 2015
    Pages: 22-30
    Received: 27 February 2015
    Accepted: 9 March 2015
    Published: 20 March 2015
    DOI: 10.11648/j.cb.s.2015030201.14
    Abstract: Mitochondria, play an important role in a variety of processes including energy production, apoptosis, autophagy and inflammation. Caspases, are proteases that play an essential role in mediating apoptotic process of programmed cell death. An association between mitochondria and caspases is very well defined during apoptosis. Besides apoptosis, eme... Show More
  • The Mechanisms of Mitochondria-Mediated Apoptosis in Cancer Chemotherapy

    Ashutosh Shrivastava

    Issue: Volume 3, Issue 2-1, April 2015
    Pages: 17-21
    Received: 3 February 2015
    Accepted: 27 February 2015
    Published: 12 March 2015
    DOI: 10.11648/j.cb.s.2015030201.13
    Abstract: Cell metabolism and signal transduction has usually been considered independent processes. Interestingly mitochondria is an intracellular organelle that perform energy production to fuel the cell to carry out its normal functions, however, in certain circumstances, its components can also carry out programmed cell destruction via its resident prote... Show More
  • Mitochondrial Alteration: A Major Player in Carcinogenesis

    Lokendra Kumar Sharma , Meenakshi Tiwari , Santosh Kumar Mishra

    Issue: Volume 3, Issue 2-1, April 2015
    Pages: 8-16
    Received: 28 January 2015
    Accepted: 28 January 2015
    Published: 10 February 2015
    DOI: 10.11648/j.cb.s.2015030201.12
    Abstract: In recent years we have witnessed mounting evidences on how a normal cell changes its cellular signaling and metabolic pathways to become highly proliferative cancer cell. Since mitochondrion is a major hub of energy production and several metabolic pathways, it is taking the center stage in defining alterations in energy homeostasis and metabolic ... Show More
  • Regulation of Mitochondrial Function by Bioactive Sphingolipids

    Rajeev Nema , Ashok Kumar

    Issue: Volume 3, Issue 2-1, April 2015
    Pages: 1-7
    Received: 24 November 2014
    Accepted: 18 December 2014
    Published: 10 February 2015
    DOI: 10.11648/j.cb.s.2015030201.11
    Abstract: Sphingolipids such as ceramide, sphingosine and sphingosine 1-phosphate [S1P] are key regulators of various cellular functions. Sphingolipids mediates of cell-stress responses and regulate mitochondrial function. Ceramide and its metabolites play an important role in the development and progression of mitochondria related disorders. Ceramide functi... Show More